|
KMID : 0545120170270061198
|
|
Journal of Microbiology and Biotechnology
2017 Volume.27 No. 6 p.1198 ~ p.1203
|
|
|
Roles of Budding Yeast Hrr25 in Recombination and Sporulation
|
|
Lee Min-Su
Joo Jeong-Hwan
Kim Keun-Pil
|
|
|
Abstract
|
|
|
|
Hrr25, a casein kinase 1 δ/ε homolog in budding yeast, is essential to set up mono-orientation of sister kinetochores during meiosis. Hrr25 kinase activity coordinates sister chromatid cohesion via cohesin phosphorylation. Here, we investigated the prophase role of Hrr25 using the auxin-inducible degron system and by ectopic expression of Hrr25 during yeast meiosis. Hrr25 mediates nuclear division in meiosis I but does not affect DNA replication. We also found that initiation of meiotic double-strand breaks as well as joint molecule formation were normal in HRR25-deficient cells. Thus, Hrr25 is essential for termination of meiotic division but not homologous recombination.
|
|
|
KEYWORD
|
|
|
Hrr25, meiosis, homologous recombination
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|